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Saturday, October 11, 2008
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Free C++ Books and Tutorials (1)
Here is the List of some of the very useful sites which contains free online books on c++ and Tutorial on c++
A Complete Guide to Programming in C++ : (Book is in RAR format ) Free
A well-written tutorial on the ANSI C++ language, suitable for either self-study or classroom work. from elementary language concepts to professional software development, with in-depth coverage of all the C++ language elements
(Link taken From www.ITeBookHome.com)
Accelerated C++: Practical Programming by Example : (Book is in RAR format ) Free
With its innovative approach to teaching the language, Accelerated C++ will challenge readers in the right way. It suggests that you don't need to learn C to be productive in C++. Written in an approachable style, it deserves a close look from any C++ novice.
(Link taken From www.flazx.com)
Advanced CORBA(R) Programming with C++ : (Book is in ZIP format ) Free
Written for the experienced C++ developer facing real-world CORBA for the first time, Advanced CORBA Programming with C++ is a useful guide to today's most popular standard for distributed computing.The authors provide numerous short excerpts of C++ code, though it must be said that much of this book is reference material rather than a hands-on programming tutorial.
(Link taken From www.flazx.com)
Ansi/Iso C++ Professional Programmer's Handbook (Que Professional Series) : (Book is in ZIP format ) Free
The ANSI/ISO C++ Professional Programmers Handbook is a concise professional C++ reference tool that presents all of the changes and addenda to the language specification. It contains tips and guidelines for exerting the full potential of C++ as a multi-purpose object-oriented programming language.
(Link taken From www.flazx.com)
Applied C++: Techniques for Building Better Software : (Book is in RAR format ) Free
Applied C is a practical, straightforward guide to developing high-quality, maintainable software. It reflects the power of C , templates, and the Standard Template Library for industrial-strength programming. Whether you are a single developer or work in a large team, the tips and techniques presented in this book will help you improve.
(Link taken From www.flazx.com)
Art of C++ : (Book is in RAR format ) Free
Learn how to apply C++ to a wide array of sophisticated applications. In his clear prose, C++ expert and the world's leading programming author Herb Schildt, shares practical, high-powered applications of C++, revealing some of the most interesting features of the language in the process.
(Link taken From www.flazx.com)
Beyond the C++ Standard Library : An Introduction to Boost : (Book is in RAR format ) Free
Introducing the Boost libraries: the next breakthrough in C++ programming. Boost takes you far beyond the C++ Standard Library, making C++ programming more elegant, robust, and productive. Now, for the first time, a leading Boost expert systematically introduces the broad set of Boost libraries and teaches best practices for their use.
(Link taken From www.flazx.com)
C++ Annotations :[Mirror][Mirror (pdf)]( free in html format ) ( tutorial)
C++ Annotation is one of the best place to find the latest documentation of c++.It covers nearly all the topics related to c++.
C++ Coding Standards: 101 Rules, Guidelines, and Best Practices : (Book is in RAR format ) Free
Consistent, high-quality coding standards improve software quality, reduce time-to-market, promote teamwork, eliminate time wasted on inconsequential matters, and simplify maintenance. Now, two of the world's most respected C++ experts distill the rich collective experience of the global C++ community into a set of coding standards that every developer and development team can understand and use as a basis for their own coding standards.
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
C++ Common Knowledge: Essential Intermediate Programming : (Book is in RAR format ) Free
What Every Professional C++ Programmer Needs to Know—Pared to Its Essentials So It Can Be Efficiently and Accurately Absorbed C++ is a large, complex language, and learning it is never entirely easy. But some concepts and techniques must be thoroughly mastered if programmers are ever to do professional-quality work.
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
C++ Cookbook (Cookbooks (O'Reilly)) : (Book is in ZIP format ) Free
Despite its highly adaptable and flexible nature, C++ is also one of the more complex programming languages to learn. Once mastered, however, it can help you organize and process information with amazing efficiency and quickness. The C++ Cookbook will make your path to mastery much shorter.
(Link taken From www.flazx.com)
C++ Cookbook : (Book is in RAR format ) Free
Despite its highly adaptable and flexible nature, C++ is also one of the more complex programming languages to learn. Once mastered, however, it can help you organize and process information with amazing efficiency and quickness. The C++ Cookbook will make your path to mastery much shorter.
(Link taken From www.ITeBookHome.com)
C++ Demystified : (Book is in CHM format ) Free
Minimal technical jargon, step-by-step discussions, and quizzes at the end of each chapter make this an easy-to-understand guide to C programming. Quickly learn what a programming language is and the anatomy of C , then jump right into creating your own programs with expert guidance. Discover functions, objects, compilers, linkers, and much more along the way.
(Link taken From www.ITeBookHome.com)
C++ FAQs, Second Edition : (Book is in RAR format ) Free (LINK Updated)
This second edition is completely up-to-date with the final ANSI/ISO C++ Standard. It covers some of the smaller syntax changes, such as "mutable"; more significant changes, such as RTTI and namespaces; and such major innovations as the C++ Standard Library, including the STL.
(Link taken From www.flazx.com)
C++ Footprint and Performance Optimization : (Book is in ZIP format ) Free
C++ Footprint and Performance Optimization contains case studies and sample code to give readers concrete examples and proven solutions to problems that don't have cut and paste solutions. The market for miniature computer programming is exploding.
(Link taken From www.flazx.com)
C++ for Business Programmers : (Book is in RAR format ) Free
This book provides a highly readable introduction to C++ programming for beginning business programmers. It guides readers through complete and clear descriptions of sample programs, with a wealth of exercises included along the way to help reinforce the important points of each chapter. Throughout the text, a strong emphasis is placed on business applications, rather than those in mathematics or computing.
(Link taken From www.ITeBookHome.com)
C++ from the Ground Up, Third Edition : (Book is in ZIP format ) Free
This excellent primer provides a plethora of C programming information for beginning to intermediate users on topics like classes, objects, expressions, arrays, pointers. Plus, it also covers advanced topics like inheritance, namespaces, STL, custom string class, and the Standard C Class Library. For users of all levels, this guide teaches with examples of source code and a thorough display of the results.
(Link taken From www.flazx.com)
C++ Gotchas: Avoiding Common Problems in Coding and Design : (Book is in ZIP format ) Free
C++ Gotchas is the professional programmer's guide to avoiding and correcting ninety-nine of the most common, destructive, and interesting C++ design and programming errors. It also serves as an inside look at the more subtle C++ features and programming techniques.
(Link taken Fro
C++ How to Program 5th Edition : (Book is in RAR format ) Free
With over 250,000 sold,
(Link taken From www.ITeBookHome.com)
C++ Network Programming, Vol. 1: Mastering Complexity with ACE and Patterns : (Book is in RAR format ) Free
Provides practical solutions for developing and optimizing complex distributed systems using the ACE, a revolutionary open-source framework that runs on dozens of hardware platforms and operating systems. Guides software professionals through the traps and pitfalls of developing efficient, portable, and flexible networked applications.
PassWord:vdown
(Link taken From www.ITeBookHome.com)
C++ Network Programming, Volume 2: Systematic Reuse with ACE and Frameworks : (Book is in RAR format ) Free
C++ Network Programming, Volume 2, focuses on ACE frameworks, providing thorough coverage of the concepts, patterns, and usage rules that form their structure. This book is a practical guide to designing object-oriented frameworks and shows developers how to apply frameworks to concurrent networked applications. Volume 2 explains how frameworks build on wrapper facades to provide higher-level communication services.
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
C++ Primer (4th Edition) Stanley B. Lippman : (Book is in RAR format ) Free (LINK Updated)
This new edition of C++ Primer, a favorite choice for a first C++ book, has been greatly improved with the latest and greatest on C++, stressing the built-in language features of the C++ Standard Library. For this new version--weighing in at a massive 1,237 pages--Stanley Lippman, a well-known C++ expert, teams up with Josée Lajoie, who has helped define the C++ international language standard. The new material is excellent for programmers who want to get the most out of new and advanced features in the language.
(Link taken From www.flazx.com)
C++ Primer Plus, Fourth Edition : (Book is in ZIP format ) Free
C++ Primer Plus, Fourth Edition presents the ANSI C++ standard beginning with a discussion of the essential elements of C++ programming: loops, expressions, functions, and classes. It walks readers through the basics of object-oriented programming: classes, inheritance, templates, and exceptions, as well as the latest object-oriented programming techniques.
PASSWORD :ebooksatkoobe
(Link taken From www.flazx.com)
C++ Template Metaprogramming : Concepts, Tools, and Techniques from Boost and Beyond : (Book is in ZIP format ) Free
C++ Template Metaprogramming" sheds light on the most powerful idioms of today's C++, at long last delivering practical metaprogramming tools and techniques into the hands of the everyday programmer.
(Link taken From www.flazx.com)
C++ Unleashed : (Book is in RAR format ) Free (LINK Updated)
Jesse Liberty's C++ Unleashed presents focused explanations of the core features and complexities of C++. The text covers advanced object-oriented analysis and design strategies and implementation issues associated
(Link taken From www.flazx.com)
C++ XML : (Book is in ZIP format ) Free
"C++ XML" is a book exclusively devoted to the power and complexities of integrating XML standards into C++. As a developer, this is a book you cannot miss. "C++ XML" addresses all major standards, toolkits, and types of applications dealing with XML as a format for representing and exchanging data, as well as XML behavior, from a C++ standpoint.
(Link taken From www.flazx.com)
C++: A Dialog: Programming with the C++ Standard Library : (Book is in ZIP format ) Free
C++: A Dialog is the easiest, most effective way for beginners to learn C++ programming. Unlike many beginners' books, C++: A Dialog uses industry-standard C++ and the latest standard librariesgiving you skills you can use with any standard C++ toolset, in any programming environment.
(Link taken From www.flazx.com)
Free C++ Books and Tutorials (2)
Creating Games in C++ : A Step-by-Step Guide : (Book is in RAR format ) Free
Author David Conger understands what other computer authors and publishers have failed to grasp: That for users like yourself, games don't represent just another fun thing to do with the computer, they're the raison d'etre for computers--and you want to start creating them the minute you start using your PC! With this in mind, David assumes no prior programming knowledge, no mathematical genius, and certainly no extensive understanding of what goes on inside PCs.
PassWord:ebooksatkoobe
(Link taken From www.ITeBookHome.com)
Data Structures and Algorithms with Object-Oriented Design Patterns in C++ :(Free in HTML format) ( tutorial)
It is a greate tutorial for learning database algorithms in C++ . It explai nearly all the commonly known algo using c++ language.(Link taken From http://www.brpreiss.com/books/opus4/html/book.html)
Design Patterns: Elements of Reusable Object-Oriented Software : (Book is in RAR format ) Free (LINK Updated)
Design Patterns is a modern classic in the literature of object-oriented development, offering timeless and elegant solutions to common problems in software design. It describes patterns for managing object creation, composing objects into larger structures, and coordinating control flow between objects. The book provides numerous examples where using composition rather than inheritance can improve the reusability and flexibility of code.
(Link taken From www.flazx.com)
Designing Components With the C Stl: A New Approach to Programming : (Book is in ZIP format ) Free
This book is the most accurate and up-to-date source of information on the STL currently available. ... It has an approach and appeal of its own: it explains techniques for building data structures and algorithms on top of the STL, and in this way appreciates the STL for what it is - a framework.
(Link taken From www.flazx.com)
Effective C++ : 55 Specific Ways to Improve Your Programs and Designs : (Book is in RAR format ) Free
This exceptionally useful text offers Scott Myers's expertise in C++ class design and programming tips. The second edition incorporates recent advances to C++ included in the ISO standard, including namespaces and built-in template classes, and is required reading for any working C++ developer.
PassWord:www.AvaxHome.ru
(Link taken From www.ITeBookHome.com)
Efficient C++ Performance Programming Techniques : (Book is in PDF format ) Free
Demonstrates the potential of C++ to produce highly efficient programs. Reveals practical, everyday object-oriented design principles and C++ coding techniques that can yield large performance improvements.
(Link taken From www.flazx.com)
Exceptional C++: 47 Engineering Puzzles, Programming Problems and Solutions : (Book is in ZIP format ) Free
Exceptional C++ shows by example how to go about sound software engineering in standard C++. Do you enjoy solving thorny C++ problems and puzzles? Do you relish writing robust and extensible code? Then take a few minutes and challenge yourself with some tough C++ design and programming problems.
(Link taken From www.flazx.com)
Financial Instrument Pricing Using C++ : (Book is in RAR format ) Free
One of the best languages for the development of financial engineering and instrument pricing applications is C++. This book has several features that allow developers to write robust, flexible and extensible software systems. The book is an ANSI/ISO standard, fully object-oriented and interfaces with many third-party applications. It has support for templates and generic programming, massive reusability using templates (write once) and support for legacy C applications.
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
Imperfect C++: Practical Solutions for Real-Life Programming : (Book is in RAR format ) Free
C++, although a marvelous language, isn't perfect. Matthew Wilson has been working with it for over a decade, and during that time he has found inherent limitations that require skillful workarounds. In this book, he doesn't just tell you what's wrong with C++, but offers practical techniques and tools for writing code that's more robust, flexible, efficient, and maintainable.
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
Memory as a Programming Concept in C and C++ : (Book is in RAR format ) Free
Assuming readers have a basic familiarity with C or C++, Frantisek Franek describes the techniques, methods and tools available to develop effective memory usage. The overwhelming majority of "bugs" and crashes in computer programming stem from problems of memory access, allocation, or deallocation. Such memory related errors are notoriously difficult to resolve.
PassWord:ebooksatkoobe
(Link taken From www.ITeBookHome.com)
Professional C++ (Programmer to Programmer) : (Book is in RAR format ) Free
* Geared to experienced C++ developers who may not be familiar with the more advanced features of the language, and therefore are not using it to its full capabilities
* Teaches programmers how to think in C++-that is, how to design effective solutions that maximize the power of the language
PassWord:www.ITeBookHome.com
(Link taken From www.ITeBookHome.com)
Programming Embedded Systems in C and C++ : (Book is in ZIP format ) Free
This book introduces embedded systems to C and C++ programmers. Topics include testing memory devices, writing and erasing Flash memory, verifying nonvolatile memory contents, controlling on-chip peripherals, device driver design and implementation, optimizing embedded code for size and speed, and making the most of C++ without a performance penalty.
(Link taken From www.flazx.com)
Schaum's Outline of Programming with C++ : (Book is in RAR format ) Free
Programming with C++ , Second Edition, is an update of the highly successful first edition a bestseller in Schaum's computer science line and reflects the new ISO standard for C++, rendering previous C++ guides obsolete. Essential for programmers, 280,000 computer science students taking first-level classes, and thousands of advanced placement students, this book is the perfect supplement to the leading textbooks in introductory and higher-level programming courses.
PassWord:ebooksatkoobe
(Link taken From www.ITeBookHome.com)
The Art of C++ : (Book is in RAR format ) Free
Learn how to apply C++ to a wide array of sophisticated applications. In his clear prose, C++ expert and the world’s leading programming author Herb Schildt, shares practical, high-powered applications of C++, revealing some of the most interesting features of the language in the process.
(Link taken From www.ITeBookHome.com)
The C++ Standard Library : A Tutorial and Reference : (Book is in RAR format ) Free (LINK Updated)
Programming with the C++ Standard Library can certainly be difficult, but Nicolai Josuttis's The C++ Standard Library provides one of the best available guides to using the built-in features of C++ effectively.
(Link taken From www.flazx.com)
Thinking in C++ (Second edition) by Bruce Eckel : [Mirror] [Mirror] (3.3 MB ) ( free in Zip[html] format ) ( Book)
it is one of the most popular book available online for c++ (Link taken From http://www.xatrix.org/)
You Can Program in C++: A Programmer's Introduction : (Book is in RAR format ) Free
An interactive and fun way to learn C++, one of the most popular high-level programming languages for graphic applications This unique, hands-on approach to learning C++ makes the experience fun and interesting by offering the opportunity for readers to get started on real coding Features numerous examples and project ideas as well as GUI and audio extensions so readers can get instant feedback.
PassWord:ebooksatkoobe
(Link taken From www.ITeBookHome.com)
Wednesday, October 8, 2008
How to Make a Big Money with Google Adsense?
Can you make thousands of dollars with google adsense? Yes, you can. Google adsense is a really money maker, and everyone can apply, and hopefully, everyone can be successful.
The bottom line is that you should obey it's policies, don't try to click the ads yourself, or ask somebody else to click the adsense ads. Please believe me google adsense team and it's equipment is much more amarter than you and me. Don't believe that some commercial softwares, claiming that they can bring you the big money. The developes of softwares would use them for themselves if they were as potent as their ads claimed.
Yes, you can make a big money with google adsense. The only thing you should do is to set up a good website with big content, and try to optimize the site. That's all. Remember, there are no shortcuts for you to be success on the internet markets besides your own efforts. Here are some good related articles for your reference.
Google Adsense Tips, Tricks, and Secrets
I've been reading a few forums and blogs about Google Adsense tips lately, and thought it would be helpful to consolidate as many as possible in one place ...www.wolf-howl.com/22/google-adsense-tips-tricks-and-secrets/
Adsense Secret
Ready to find out a huge adsense secret? Of course you are! Joal Comm writes about the number one mistake that people can make when displaying their adsense ...www.internetbasedmoms.com/affiliates/adsense-secret.html
Adsense Tips, Layout Optimization Tricks for Higher CTR - Digital ...
Google Adsense is perhaps the easiest way to attract advertisers from across the globe to your blog. Just submit your blog to Google for approval. ...labnol.blogspot.com/2005/09/z-adsense-tips-for-increasing-revenue.html
Adsense Secrets & Adsense Resource
Many of you with websites know that you can make a great extra income with Google's Adsense program. Below are links and resources to tips and secrets on ...www.mommyportal.com/adsense.htm
Unlock the Secrets of AdSense by Choosing the Best AdSense Keywords
Unlock the Secrets of AdSense by Choosing the Best AdSense Keywords. ... Google AdSense Income Secrets - How to Make Massive Profits From AdSense ...ezinearticles.com/?Unlock-the-Secrets-of-AdSense-by-Choosing-the-Best-AdSense-Keywords&id=1368441
The super secret AdSense revenue share is finally revealed
People would be hesitant to click on their own adsense ads because Google has their secret police and advanaced algorithms to detect it. ...www.webmasterworld.com/forum89/11568.htm
The Infamous Secret To Google AdSense
The only AdSense secret you need to know is how to find high paying keywords. ... The placement of your Google AdSense ads is another AdSense secret - or so ...www.revenow.com/articles/13/1/The-Infamous-Secret-To-Google-AdSense
5 Top Secret Techniques To Make Your Adsense Website Stick - Keywords
Without a doubt you need traffic to your Adsense website since your income from Google depends on it. It's the problem which most people have problems with.articles.directorym.net/5_Top_Secret_Techniques_To_Make_Your_Adsense_Website_Stick-a868081.html
Adsense Secrets - Blog Toplist
Dec 22, 2007 ... Blog Details for Adsense Secrets. ... Adsense Secrets now with videos, photos and articles to gain high revenue from adsense ...www.blogtoplist.com/marketing-seo/blogdetails-27498.html
Adsense Tricks.org Learn Secrets to Adsense and how to Make ...
Adsense Tricks.org Learn Google AdSense Tricks, AdSense Secrets, How to Make Money with Adsense Adsense for web site tips.www.adsensetricks.org/
How to Make an AdSense Arbitrage Machine
Like any other business, AdSense Arbitrage has some secrets and you can not ..... Another secret in Adsense Arbitrage business is hidden in the bidding on ...www.weboma.com/how-to-make-an-adsense-arbitrage-machine/
Secret AdSense Tips and Tricks
Oct 22, 2007 ... There really aren't many secrets to AdSense, just common sense and testing. There are plenty of places out ...
impnerd.com/web-development/secret-adsense-tips-and-tricks
Google Sends Secret AdSense Online Advisory Council Invites
Google is sending out invitations to select top Google Adsense publishers to join the AdSense Online Advisory Council, a select group of publishers who ...www.quickonlinetips.com/archives/2007/08/google-sends-secret-adsense-online-advisory-council-invites/
WebGuru.ws: Beware of... Adsense Secrets
Oct 10, 2006 ... But there is another problem that we must be aware of: the Adsense scams. Many of them calls their selfs "Adsense Secrets". ...www.webguru.ws/2006/10/beware-of-adsense-secrets.html -
Sunday, October 5, 2008
How to Make a Big Money?
How to make big money - Forbes.com- msnbc.com
Mar 29, 2007 ... An unprecedented number of Americans have received unprecedented incomes and accumulated unprecedented net worth in recent years.www.msnbc.msn.com/id/17856958/
How to Make Big Money Selling Fake Art on eBay
Well, fret no more because now you can make big money selling fake art on eBay. (It's OK; eBay doesn't care.) You say you know nothing about art? ...www.artbusiness.com/faketutorial.html
Make Money Online
Make Money online with proven techniques from Internet marketing experts. Learn how to make big money online with integrity.www.canimakebigmoneyonline.com/
Make Big Money!!!
For more information go to: http://www.makebigmoney.com and find out how to MAKE BIG MONEY!!!. Sincerely, Marv and Lolita Fetterman Chief Executive Officers ...www.mattneuman.com/bigmoney.htm
Amazon.com: How to Make Big Money in Your Own Small Business ...
Amazon.com: How to Make Big Money in Your Own Small Business: Unexpected Rules Every Small Business Owner Needs to Know: Jeffrey J. Fox: Books.www.amazon.com/Make-Money-Your-Small-Business/dp/0786868252
How To Make Big Money - Forbes.com
How do the rich get rich? Luck often plays a role, but here are 11 time-tested strategies that are being vigorously pursued--and that work.www.forbes.com/2007/03/27/ford-home-depot-pf-guru-in_gs_0327soapbox_inl.html
Queens Crap: Port Authority Workers Make Big Money
Port Authority Workers Make Big Money. HACKENSACK, NJ (AP) -- One-sixth of the employees at the Port Authority of New York and New Jersey have base salaries ...queenscrap.blogspot.com/2008/09/port-authority-workers-make-big-money.html
How to Make Big Money Investing in Domain Names - Part 1 PodTech.net
Oct 9, 2007 ... How to Make Big Money Investing in Domain Names: This video posted on PodTech will give you some sound advice from the CEO of Moniker on how ...www.podtech.net/home/4347/how-to-make-big-money-investing-in-domain-names-part-1
How to Make BIG Money on Facebook! Marketing Profs Daily Fix Blog
So I wrote a premium article for MarketingProfs that walks companies through the steps necessary to make BIG money on Facebook, and on any social ...www.mpdailyfix.com/2007/10/how_to_make_big_money_on_faceb.html
Find the Best Affiliate Programs - Make Big Money Online with ...
At AffiliateTips.com visitors will find the best affiliate programs ranked, reviewed and delivered offering you the chance of making money online on what we ...www.affiliatetips.com/
How to Lose Weight Fast?
How to Lose Weight Fast - wikiHow
wikiHow article about How to Lose Weight Fast. ... Any health strategy should include both, but if you want to lose weight fast, exercise is essential. ...www.wikihow.com/Lose-Weight-Fast
YouTube - How To Lose Weight Fast and Easy
This tells how I lost over 100 pounds, hope you can make some ...3 min 54 sec –
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Lose Weight Fast - AOL Health
Whether it's a reunion or a big date in your near future AOL Body has tips to help you lose weight fast.www.aolhealth.com/diet/basics/lose-weight-fast
Fast weight loss programs & Body sculpting exercises that work
How to lose weight fast & Look good naked! in 7 easy steps .... i need to lose weight fast for a wedding and was considering doing a juice fast. i was ...www.nowloss.com
Want to Lose Weight? Exercise!
After a few weeks or months, those who exercise to lose weight can work up to an ..... No one can tell you exactly how far or how fast to walk at the start, ...www.healthgoods.com/education/fitness_information/general_fitness_information/want_to_lose_weight.htm
Weight loss, losing extra pounds, easy diets and a fast diet
Well, If you want to lose weight fast, you need to be more patient. .... Giving up on diets or exercise is okay. You can give up on your diet for a few days ...advice7.com/health_fitness/diets.html
Excercises to Lose Weight Fast
Excercises to Lose Weight Fast - What are the Choices? The good news is that virtually any exercise will do. There isn't one magical exercise better than ...weightlossinternational.com/newsletter/excercises-to-lose-weight-fast.html
Research Progresses on "Obesity and Diabetes"--2
11: J Clin Invest. 2008 Oct;118(10):3247-59.
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Molecular processes that handle - and mishandle - dietary lipids.Williams KJ.Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation - but possible reversibility - in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.PMID: 18830418 [PubMed - in process]
12: J Hum Hypertens. 2008 Oct 2. [Epub ahead of print]
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Ethnic variation in hypertension prevalence of women in Taiwan.Su TC, Hwang LC, You SL, Chen CJ.1Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.The prevalence and risk factors of hypertension vary in ethnic groups. This study aimed to estimate the hypertension prevalence and to compare risk factors associated with hypertension in women of four ethnic groups in Taiwan. The study subjects were participants in the Taiwanese Survey on Hypertension, Hyperglycemia and Hyperlipidemia (TwSHHH) enrolled in 2002. In this analysis, only 2810 women who were at age of 20-80 years old and whose father and mother had same ethnic background (Minnan, Hakka, Aborigines or Mainland Chinese) were included. Results showed that there were significant ethnic differences in the prevalence of hypertension, obesity indices, fasting glucose, dyslipidaemia, hyperuricaemia, history of alcohol drinking and tobacco smoking and socioeconomic status. Aborigines had the highest prevalence of hypertension (28.6%) and diabetes mellitus (8.9%), whereas the Minnan group had the second highest prevalence of hypertension (19.2%) and diabetes mellitus (7.9%). Both age and central obesity were associated with an increased prevalence of hypertension except central obesity in Mainland Chinese in all four ethnic groups. Compared with the Mainland Chinese as the referent, the multivariate-adjusted odds ratio (OR) (95% CI) was 1.19 (0.63-2.26), 1.92 (1.15-3.21) and 2.03 (1.00-4.12) for Hakka, Minnan and Aborigines, respectively. Elevated body mass index (>/=27.0 vs <24.0 kg m(-2)) and central obesity were significantly associated with hypertension showing multivariate-adjusted OR (95% CI) of 1.68 (1.18-2.38) and 1.95 (1.48-2.57), respectively. In addition, dyslipidaemia, hyperuricaemia and diabetes associated with higher OR for hypertension in Minnan women. In conclusion, there were ethnic variations in hypertension prevalence and determinants in Taiwanese women.Journal of Human Hypertension advance online publication, 2 October 2008; doi:10.1038/jhh.2008.120.PMID: 18830252 [PubMed - as supplied by publisher]
13: Eur J Cardiovasc Prev Rehabil. 2008 Oct;15(5):589-593.
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Adherence to a Mediterranean-type diet and reduced prevalence of clustered cardiovascular risk factors in a cohort of 3204 high-risk patients.Sánchez-Taínta A, Estruch R, Bulló M, Corella D, Gómez-Gracia E, Fiol M, Algorta J, Covas MI, Lapetra J, Zazpe I, Ruiz-Gutiérrez V, Ros E, Martínez-González MA; for the PREDIMED group.aDepartment of Preventive Medicine and Public Health, Clínica Universitaria-University of Navarra, Irunlarrea, Pamplona bDepartment of Internal Medicine, Hospital Clinic, Villarroel, Barcelona cHuman Nutrition Department, School of Medicine, University Rovira i Virgili, Sant Llorenç, Reus dDepartment of Preventive Medicine, School of Medicine, University of Valencia, Avda Blasco Ibáñez, Valencia eDepartment of Epidemiology, School of Medicine, University of Malaga, Campus de Teatinos s/n, Málaga fDepartment of Cardiology, University Hospital Son Dureta Andrea Doria, Mallorca gUnit of Clinical Trials, Hospital Txagorritxu, José Achotegui s/n, Vitoria hCardiovascular Epidemiology Unit, Municipal Institut for Medical Research, Dr. Aiguader, Barcelona iDepartment of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Damasco s/n jDepartment of Nutrition and Food Sciences, Physiology and Toxicology, Clínica Universitaria-University of Navarra, Irunlarrea, Pamplona kInstituto de la Grasa, Consejo Superior de Investigaciones Científicas, Avda Padre García Tejero, Sevilla lCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.BACKGROUND: The Mediterranean food pattern (MeDiet) has been suggested to have beneficial effects on cardiovascular risk factors. Scarcity of assessment of this effect on large samples of patients at high risk is, however, observed. Our objective was to estimate the association between adherence to MeDiet and the prevalence of risk factors in 3204 asymptomatic high-risk patients. DESIGN: Cross-sectional assessment of baseline characteristics of participants in a primary prevention trial. METHODS: Participants were assessed by their usual primary-care physicians to ascertain the prevalence of diet-related cardiovascular risk factors (diabetes, hypertension, dyslipidemia, or obesity) using standard diagnostic criteria. A dietitian interviewed each participant to obtain a 14-point score measuring the degree of adherence to MeDiet. RESULTS: Adherence to MeDiet was inversely associated with individual risk factors and, above all, with the clustering of them. The multivariate adjusted odds ratio to present simultaneously the four risk factors for those above the median value of the MeDiet score was 0.67 (95% confidence interval: 0.53-0.85). The multivariate odds ratios for successive categories of adherence to MeDiet were 1 (ref.), 1.03, 0.85, 0.70 and 0.54 (P for trend <0.001). CONCLUSION: Following a MeDiet was inversely associated with the clustering of hypertension, diabetes, obesity, and hypercholesterolemia among high-risk patients.PMID: 18830087 [PubMed - as supplied by publisher]
14: Eur J Cardiovasc Prev Rehabil. 2008 Oct;15(5):503-508.
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Screen detection and the WHO STEPwise approach to the prevalence and risk factors of arterial hypertension in Kinshasa.Longo-Mbenza B, Ngoma DV, Nahimana D, Mayuku DM, Fuele SM, Ekwanzala F, Beya C.aDivision of Cardiology, University of Kinshasa bNational Programme of Nutrition, Biostatistics, Ministry of Health cLOMO MEDICAL, Clinical Epidemiology dWorld Health Organisation Representation in Democratic Republic of Congo eMinistry of Public Health, Kinshasa, Democratic Republic of Congo.BACKGROUND: The trend of hypertension and other risk factors of cardiovascular disease is changing because of epidemiological, demographic and nutritional transitions in sub-Saharan Africa. OBJECTIVES: The aim of this study is to determine the prevalence and risk factors of arterial hypertension in the Kinshasa region, Democratic Republic of Congo (DRC). DESIGN AND METHODS: Data were collected from random sample cross-sectional surveys of adult black Africans from Kinshasa, with the help of a structured questionnaire, physical examinations and blood samples, using the World Health Organisation (WHO) stepwise approach. Sex, age, place of residence (urban versus rural), psychosocial risk factors (socioeconomic status, stress), overweight status (BMI: 25-29.9 kg/m), general obesity (BMI: >/=30 kg/m), abdominal obesity (waist circumference: >/=94 cm) and diabetes mellitus were considered to be the potential risk factors for screen-detected hypertension. RESULTS: The weighted prevalences of hypertension, diabetes mellitus, overweight status, general obesity and abdominal obesity were 15.2, 140.2, 13.5, 4.8 and 7.5%, respectively. Blood pressure and the proportion of participants with hypertension increased with age and BMI group in the population, for both men and women. Age, rural residence, low socioeconomic status, high socioeconomic status, general obesity and abdominal obesity were the risk factors for hypertension. Women aged 55 years and above had higher levels of blood pressure and hypertension than men. CONCLUSION: Absolute levels of hypertension, all types of obesity and diabetes mellitus are high risk factors in the army camps and semiurban extension cities; general obesity and abdominal obesity are the risk factors for detectable hypertension. Effective control of general obesity and abdominal obesity and psychosocial strategies that target both semirural and urban areas of the Kinshasa region have the potential to prevent much premature cardiovascular disease.PMID: 18830083 [PubMed - as supplied by publisher]
15: Diabetes. 2008 Oct 1. [Epub ahead of print]
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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.Lumeng CN, Delproposto JB, Westcott DJ, Saltiel AR.Life Sciences Institute, University of Michigan, Ann Arbor, MI.Objective: To establish the mechanism of the phenotypic switch of adipose tissue macrophages from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity. Research Design and Methods: ATMs from lean and obese (high fat diet fed) C57Bl/6 mice were analyzed by a combination of flow cytometry, immunofluorescence, and expression analysis for M2a and M1 genes. Pulse labeling of ATMs with PKH26 assessed the recruitment rate of ATMs to spatially distinct regions. Results: Resident ATMs in lean mice express the M2a marker MGL1 and localize to interstitial spaces between adipocytes independent of CCR2 and CCL2. With diet-induced obesity, MGL1(+) ATMs remain in interstitial spaces, while a population of MGL1(-)CCR2(+) ATMs with high M1 and low M2a gene expression is recruited to clusters surrounding necrotic adipocytes. Pulse labeling showed that the rate of recruitment of new macrophages to MGL1(-) ATM clusters is significantly faster than that of interstitial MGL1(+) ATMs. This recruitment is attenuated in Ccr2(-/-) mice. M2a and M1 polarized macrophages produced different effects on adipogenesis and adipocyte insulin sensitivity in vitro. Conclusions: The shift in the M2a/M1 ATM balance is generated by spatial and temporal differences in the recruitment of distinct ATM subtypes. The obesity-induced switch in ATM activation state is coupled to the localized recruitment of an inflammatory ATM subtype to macrophage clusters from the circulation, and not to the conversion of resident M2a macrophages to M1 ATMs in situ.PMID: 18829989 [PubMed - as supplied by publisher]
16: J Public Health (Oxf). 2008 Sep 30. [Epub ahead of print]
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Prevalence of prehypertension and hypertension and associated risk factors among Turkish adults: Trabzon Hypertension Study.Erem C, Hacihasanoglu A, Kocak M, Deger O, Topbas M.Karadeniz Technical University, Faculty of Medicine,Department of Internal Medicine, Division of Endocrinology and Metabolism, The Trabzon Endocrinological Studies Group, Trabzon, Turkey.BACKGROUND: To estimate the prevalence, awareness and control of prehypertension (preHT) and hypertension (HT) as defined by JNC-7 criteria in the Trabzon Region and its associations with demographic factors (age, sex, obesity, marital status, reproductive history in women and level of education), socioeconomic factors (household income and occupation), family history of selected medical conditions (diabetes, hypertension, obesity and cardiovascular disease), lifestyle factors (smoking habits, physical activity and alcohol consumption) in the adult population. METHODS: In this cross-sectional survey, a sample of households was systematically selected from the central province of Trabzon and its nine towns. A total of 4809 adult subjects (2601 women and 2208 men) were included in the study. Demographic and socioeconomic factors, family history of selected medical conditions, and lifestyle factors were obtained for all participants. Systolic blood pressure (BP) and diastolic BP levels were measured for all subjects. The persons included in the questionnaire were invited to the local medical centers for blood examination between 08:00-10:00 following 12 hours of fasting. The levels of serum glucose (FBG), total cholesterol (Total-C), high density cholesterol (HDL-C), low density cholesterol (LDL-C) and triglycerides were measured with autoanalyzer. Definition and classification of HT was performed according to guidelines from the US JNC-7 report. Prevalence, awareness, treatment and control of HT were assessed. RESULTS: The prevalences of HT and preHT were 44.0% (46.1% in women and 41.6% in men) and 14.5% (12.6% in women and 16.8% in men), respectively. Overall, only 41% of the hypertensive individuals had been previously diagnosed. Furthermore, 54.5% of the hypertensive subjects were being treated with antihypertensive drugs (AHD), but only 24.3% of treated subjects had their BP adequately controlled. Among all hypertensive subjects (known and newly diagnosed), only 5.43% had their BP under control. The prevalence of HT increased with age, being highest in the 60- to 69-year-old age group (84.4%) but lower again in the 70+ age group. Interestingly, the prevalence was 16.9% in the 20-to 29-year old age group. HT was associated positively with marital status, parity, cessation of cigarette smoking, and negatively with level of education, alcohol consumption, current cigarette use, and physical activity. Multinomial logistic regression analysis revealed that HT were significantly associated with age, male gender, BMI, low education level, nonsmoking, positive family history of selected medical conditions, occupation, and parity. CONCLUSIONS: The Trabzon Hypertension Study data indicated that HT is very common and is an important health problem in the adult population of Trabzon. Patients who are unaware of their status and treated uncontrolled hypertensives are at high risk of early cardiovascular morbidity and mortality. To control preHT and HT, effective public health education and urgent precautions are needed. The precautions include serious health education, a well-balanced diet and increasing physical activity.PMID: 18829520 [PubMed - as supplied by publisher]
17: Diabetes Metab. 2008 Sep 29. [Epub ahead of print]
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The metabolic syndrome, diabetes and lung dysfunction.Tiengo A, Fadini GP, Avogaro A.Division of Metabolic Diseases, Department of Clinical Medicine, University of Padova, Padova, Italy.Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due to a shared inflammatory process. Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction.PMID: 18829364 [PubMed - as supplied by publisher]
18: J Nutr Biochem. 2008 Sep 29. [Epub ahead of print]
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Fasting triacylglycerol status, but not polyunsaturated/saturated fatty acid ratio, influences the postprandial response to a series of oral fat tolerance tests.Dekker MJ, Wright AJ, Mazurak VC, Marangoni AG, Rush JW, Graham TE, Robinson LE.Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.Elevated postprandial lipemia is emerging as a risk factor for obesity-related chronic diseases, such as type 2 diabetes and cardiovascular disease, and is associated with alterations in several metabolic biomarkers of disease. Our goal was to examine the effects of specific polyunsaturated/saturated fatty acid (P/S) ratios on postprandial triacylglycerol (TAG) concentrations and metabolic biomarkers in men with different fasting TAG concentrations through a series of oral fat tolerance tests (OFTT) consisting solely of emulsified lipid. Otherwise healthy men with high (>1.69 mmol/L) fasting TAG (HTAG, n=8) and low fasting TAG (LTAG, n=8) underwent three OFTTs with specific P/S ratios of 0.2, 1.0 and 2.0, respectively, and a total lipid load of 1 g/kg subject body mass. All subjects received each treatment separated by at least 1 week. Postprandial plasma TAG fatty acid composition reflected fatty acids present in the OFTT. All other metabolic responses were independent of the P/S ratio ingested. An accelerated increase in postprandial TAGs was observed in HTAG compared to LTAG. Interleukin (IL)-6 and soluble intercellular adhesion molecule (sICAM)-1 were significantly elevated in HTAG at baseline (P<.05). IL-6 increased significantly following each OFTT (P<.05) in both groups. Postprandial glucose and CRP were significantly exaggerated (P<.05) in HTAG. Overall, HTAG subjects had an accelerated postprandial TAG response and increased concentrations of several inflammatory markers following an OFTT, in the absence of an insulin response. However, P/S ratio had no influence on postprandial lipid and inflammatory parameters.PMID: 18829281 [PubMed - as supplied by publisher]
19: Twin Res Hum Genet. 2008 Oct;11(5):505-516.
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Anthropometry, Carbohydrate and Lipid Metabolism in the East Flanders Prospective Twin Survey: Linkage of Candidate Genes Using Two Sib-Pair Based Variance Components Analyses.Souren NY, Zeegers MP, Janssen RG, Steyls A, Gielen M, Loos RJ, Beunen G, Fagard R, Stassen AP, Aerssens J, Derom C, Vlietinck R, Paulussen AD.1 Department of Complex Genetics, Maastricht University, the Netherlands; Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, the Netherlands; Unit of Genetic Epidemiology, Department of Public Health and Epidemiology, University of Birmingham, United Kingdom.Abstract Insulin resistance and obesity are underlying causes of type 2 diabetes and therefore much interest is focused on the potential genes involved. A series of anthropometric and metabolic characteristic were measured in 240 MZ and 112 DZ twin pairs recruited from the East Flanders Prospective Twin Survey. Microsatellite markers located close to ABCC8, ADIPOQ, GCK, IGF1, IGFBP1, INSR, LEP, LEPR, PPARgamma and the RETN gene were genotyped. Univariate single point variance components linkage analyses were performed using two methods: (1) the standard method, only comprising the phenotypic and genotypic data of the DZ twin pairs and (2) the extended method, also incorporating the phenotypic data of the MZ twin pairs. Suggestive linkages (LOD > 1) were observed between the ABCC8 marker and waist-to-hip ratio and HDL-cholesterol levels. Both markers flanking ADIPOQ showed suggestive linkage with triglycerides levels, the upstream marker also with body mass and HDL-cholesterol levels. The IGFBP1 marker showed suggestive linkage with fat mass, fasting insulin and leptin levels and the LEP marker showed suggestive linkage with birth weight. This study suggests that DNA variants in ABCC8, ADIPOQ, IGFBP1 and LEP gene region may predispose to type 2 diabetes. In addition, the two methods used to perform linkage analyses yielded similar results. This was however not the case for birth weight where chorionicity seems to be an important confounder.PMID: 18828733 [PubMed - as supplied by publisher]
20: Mt Sinai J Med. 2008 Sep 30;75(5):454-459. [Epub ahead of print]
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Impact of obesity on hospitalized patients.Markoff B, Amsterdam A.Division of General Internal Medicine, Department of Medicine, Mount Sinai Medical Center, New York, NY.Obesity is increasing at an alarming rate worldwide and is a risk factor for cardiac disease, diabetes, and stroke. This provides a challenge for the physicians caring for this patient population in the hospital. Skin integrity, medication dosing, testing, and nutrition are all altered by obesity. We summarize some of the current data on caring for the obese inpatient. Unfortunately, few data on this unique inpatient population exist. Mt Sinai J Med 75:454-459, 2008. (c) 2008 Mount Sinai School of Medicine.PMID: 18828168 [PubMed - as supplied by publisher]
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